There is currently great controversy over the contribution antimicrobial use in animal agriculture has made to antimicrobial resistance in pathogenic bacteria with negative consequences for human health. In light of this, the approval process for antimicrobials used in US animal agriculture, known as New Animal Drug Application or NADA, is currently being revised by the federal government. We explore the public deliberations over the development of these new policies focusing our attention on the interaction between pharmaceutical companies and the U.S. (...) Food and Drug Administration. What appears to be an antagonistic public discourse is examined in terms of its ability to simultaneously legitimate the roles of the Food and Drug Administration as the official arbiter of policy on antimicrobial use in animal agriculture and as a protector of the public welfare, as well as the role of pharmaceutical companies as the producers of safe and effective products necessary for the protection of public well-being. (shrink)

This book is the third in a series based on conferences sponsored by the Metroplex Institute for Neural Dynamics, an interdisciplinary organization of neural ...

The articles comprising this thematic symposium suggest options for exploring the nexus between freedom and unfreedom, as exemplified by the British abolitionists’ anti-slavery campaign and the paradox of freedom. Each article has implications for how these abolitionists achieved their goals, social activists’ efforts to secure reparations for slave ancestors, and modern slavery. We present the abolitionists’ undertaking as a marketing campaign, highlighting the role of instilling moral agency and indignation through re-humanizing the dehumanized. Despite this campaign’s eventual success, its post-emancipation (...) phase illustrates a paradox of freedom. After introducing mystification as an explanation for the obscuring rhetoric used to conceal post-emancipation violations of freedom during the West’s colonial phase, we briefly discuss the appropriateness of reparations. Finally, we discuss the contributions made by the articles in this thematic symposium. (shrink)

Intelligent design theorist William Dembski hasproposed an ``explanatory filter'' fordistinguishing between events due to chance,lawful regularity or design. We show that ifDembski's filter were adopted as a scientificheuristic, some classical developments inscience would not be rational, and thatDembski's assertion that the filter reliablyidentifies rarefied design requires ignoringthe state of background knowledge. Ifbackground information changes even slightly,the filter's conclusion will vary wildly.Dembski fails to overcome Hume's objections toarguments from design.

Human culture is uniquely complex compared to other species. This complexity stems from the accumulation of culture over time through high- and low-fidelity transmission and innovation. One possible reason for why humans retain and create culture, is our ability to modulate teaching strategies in order to foster learning and innovation. We argue that teaching is more diverse, flexible, and complex in humans than in other species. This particular characteristic of human teaching rather than teaching itself is one of the reasons (...) for human’s incredible capacity for cumulative culture. That is, humans unlike other species can signal to learners whether the information they are teaching can or cannot be modified. As a result teaching in humans can be used to support high or low fidelity transmission, innovation, and ultimately, cumulative culture. (shrink)

The article explores the concept of infodemics during the COVID-19 pandemic, focusing on the propagation of false or inaccurate information proliferating worldwide throughout the SARS-CoV-2 health crisis. We provide an overview of disinformation, misinformation and malinformation and discuss the notion of “fake news”, and highlight the threats these phenomena bear for health policies and national and international security. We discuss the mis-/disinformation as a significant challenge to the public health, intelligence, and policymaking communities and highlight the necessity to design measures (...) enabling the prevention, interdiction, and mitigation of such threats. We then present an overview of selected opportunities for applying technology to study and combat disinformation, outlining several approaches currently being used to understand, describe, and model the phenomena of misinformation and disinformation. We focus specifically on complex networks, machine learning, data- and text-mining methods in misinformation detection, sentiment analysis, and agent-based models of misinformation spreading and the detection of misinformation sources in the network. We conclude with the set of recommendations supporting the World Health Organization’s initiative on infodemiology. We support the implementation of integrated preventive procedures and internationalization of infodemic management. We also endorse the application of the cross-disciplinary methodology of Crime Science discipline, supplemented by Big Data analysis and related information technologies to prevent, disrupt, and detect mis- and disinformation efficiently. (shrink)

Three experiments investigated response times for remember and know responses in recognition memory. RTs to remember responses were faster than RTs to know responses, regardless of whether the remember–know decision was preceded by an old/new decision or was made without a preceding old/new decision . The finding of faster RTs for R responses was also found when remember–know decisions were made retrospectively. These findings are inconsistent with dual-process models of recognition memory, which predict that recollection is slower and more effortful (...) than familiarity. Word frequency did not influence RTs, but remember responses were faster for words than for nonwords. We argue that the difference in RTs to remember and know responses reflects the time taken to make old/new decisions on the basis of the type of information activated at test. (shrink)

This chapter outlines the theoretical deep structure that is common to Durkheim's social psychology and the general theory of action. It first demonstrates the limits of the intellectual-historicist approach to classic sociology (Jones, 1977). It then induces the generative theoretical paradigm of Suicide from a textual analysis. It concludes by demonstrating the formal and substantive equivalence of this paradigm to the four-function general action system of Talcott Parsons.

My dissertation concerns the nature of linguistic understanding. A standard view about linguistic understanding is that it is a propositional knowledge state. The following is an instance of this view: given a speaker S and an expression alpha that means M, S understand alpha just in case S knows that alpha means M. I refer to this as the epistemic view of linguistic understanding. The epistemic view would appear to be a mere conceptual truth about linguistic understanding, since it is (...) entailed by the following two claims that themselves seem to be mere conceptual truths: S understands alpha iff S knows what alpha means, and---given that a means M--- S knows what alpha means iff S knows that alpha means M. I argue, however, that this is not a mere conceptual truth. Contrary to the epistemic view, propositional knowledge of the meaning of alpha is not necessary for understanding alpha. I argue that linguistic understanding does not even require belief. My positive proposal is that our understanding of language is typically realized, at least in native speakers, as a perceptual capacity. Evidence from cognitive neuropsychology suggests that our perceptual experience of language comes to us already semantically interpreted. We perceive a speaker's utterance as having content, and it is by perceiving the speaker's utterances as having the right content that we understand what the speaker says. We count as understanding language in virtue of having this capacity to understand what speakers say when they use language. This notion of perceiving an utterance as having content gets analyzed in terms of Dretske's account of representation in terms of a teleological notion of function: you perceive a speaker's utterance as having content when the utterance produces in you a perceptual state that has a certain function in your psychology. I show how this view about the nature of linguistic understanding provides an attractive account of how identity claims can be semantically informative, as opposed to merely pragmatically informative, an account that avoids the standard difficulties for Fregean views that attempt to account for the informativeness of identity claims in terms of their semantics. (shrink)

Despite a large and multifaceted effort to understand the vast landscape of phenotypic data, their current form inhibits productive data analysis. The lack of a community-wide, consensus-based, human- and machine-interpretable language for describing phenotypes and their genomic and environmental contexts is perhaps the most pressing scientific bottleneck to integration across many key fields in biology, including genomics, systems biology, development, medicine, evolution, ecology, and systematics. Here we survey the current phenomics landscape, including data resources and handling, and the progress that (...) has been made to accurately capture relevant data descriptions for phenotypes. We present an example of the kind of integration across domains that computable phenotypes would enable, and we call upon the broader biology community, publishers, and relevant funding agencies to support efforts to surmount today's data barriers and facilitate analytical reproducibility. (shrink)

How do educators better reach their students, better capture their attention and imagination without sacrificing scholarship? Teachable Moments: Essays on Experiential Education examines the pedagogy of Prescott College, a school that has embraced experiential education and been finding success with it for over thirty years. These essays—from scholars in fields as wide ranging as religious studies, environmental science, psychology, dance, literature, adventure education, and peace studies—examine the challenges and, ultimately, the rewards of student-centered education.

Knobe (2003a, 2003b, 2004b) and others have demonstrated the surprising fact that the valence of a side-effect action can affect intuitions about whether that action was performed intentionally. Here we report the results of an experiment that extends these findings by testing for an analogous effect regarding knowledge attributions. Our results suggest that subjects are less likely to find that an agent knows an action will bring about a side-effect when the effect is good than when it is bad. It (...) is further argued that these findings, while preliminary, have important implications for recent debates within epistemology about the relationship between knowledge and action. (shrink)

Background: Genomic analysis may reveal both primary and secondary findings with direct relevance to the health of probands’ biological relatives. Researchers question their obligations to return findings not only to participants but also to family members. Given the social value of privacy protection, should researchers offer a proband’s results to family members, including after the proband’s death? Methods: Preferences were elicited using interviews and a survey. Respondents included probands from two pancreatic cancer research resources, plus biological and nonbiological family members. (...) Hypothetical scenarios based on actual research findings from the two cancer research resources were presented; participants were asked return of results preferences and justifications. Interview transcripts were coded and analyzed; survey data were analyzed descriptively. Results: Fifty-one individuals (17 probands, 21 biological relatives, 13 spouses/partners) were interviewed. Subsequently, a mailed survey was returned by 464 probands, 1,040 biological family members, and 399 spouses/partners. This analysis highlights the interviews, augmented by survey findings. Probands and family members attribute great predictive power and lifesaving potential to genomic information. A majority hold that a proband’s genomic results relevant to family members’ health ought to be offered. While informants endorse each individual’s choice whether to learn results, most express a strong moral responsibility to know and to share, particularly with the younger generation. Most have few concerns about sharing genetic information within the family; rather, their concerns focus on the health consequences of not sharing. Conclusions: Although additional studies in diverse populations are needed, policies governing return of genomic results should consider how families understand genomic data, how they value confidentiality within the family, and whether they endorse an ethics of sharing. A focus on respect for individual privacy—without attention to how the broad social and cultural context shapes preferences within families—cannot be the sole foundation of policy. (shrink)

Pragmatic comparative effectiveness randomized controlled trials evaluate the effectiveness of one interventions under real-world clinical conditions. The results of ceRCTs are often directly generalizable to everyday clinical practice, providing information critical to decision-making by patients, clinicians, and healthcare policymakers. The PRECIS-2 framework identifies nine domains that serve to score a trial on a continuum between very explanatory to very pragmatic. According to the framework, pragmatic trials may have one or more of the following features: there are fewer eligibility criteria for (...) participants, in an... (shrink)

Though the name of Robert Mallet was once inevitably associated with the scientific study of earthquakes, it is less well known today. As part of an overdue reappraisal, this essay examines Mallet's major seismological projects and publications, emphasizing his theoretical contributions. Mallet's own claim to be a founder of modern seismology is upheld. Beyond that, however, he is also seen to be an important precursor of plate tectonics.

Benjamin Franklin, the colonial American, maintained a now little-known interest in geological questions for more than sixty years. He began as a follower of English theorists, but soon assimilated some of their ideas with original speculations and discoveries, particularly regarding earthquakes. Though Franklin became famous for his experiments with electricity, he never attempted to explain earthquakes as if they were electrical phenomena; others, however, did. Through his access to American materials, Franklin contributed significantly to the work of several English and (...) French geological theorists. Though some of his own theories were ultimately of limited value, Franklin played an important role in the international science of his time. In addition to his other accomplishments, he was colonial America's foremost student of geology. (shrink)

Although the history of the word ‘ geology ’ has often been referred to by those interested in the development of the science, that history has never been fully traced. An endeavor is made to do so here, taking the story at least as far as 1813, by which time the basic word had unquestionably been established in its modern form and meaning. Various claims as to who first gave the science its present name are also briefly examined.

In “Revive and Refuse,” Marshall et al. (2024) argue that many individuals who are revived from opioid overdoses have diminished decision-making capacity (DMC), given that so many of them have opio...

James Hutton knew before its publication that his geological theory would be subjected to religious criticism, and in an eventually rejected preface he endeavoured to mitigate that criticism. His theory is an almost perfect expression of the deistic tenets in which he believed. But he sensed that his attempted defence was inadequate, and so he submitted his preface to William Robertson for advice. Robertson rewrote Hutton's preface for him but also suggested tactfully that it not be published, advice which Hutton (...) took. Upon publication, his theory received its full measure of religious opposition, but it is unlikely that Hutton's preface would have forestalled any of it. I transcribe and attempt to date the preface, discuss its contents, and suggest its usefulness in Huttonian studies. (shrink)

Though virtually unknown before 1851, the exceptionally scenic Yosemite Valley of California soon attracted continuing attention as a geological anomaly. J. D. Whitney, state geologist and Harvard professor, advocated a tectonic theory of its origin. Despite its seemingly official status, Whitney's theory even failed to convince some of his own subordinates. An unexpectedly effective dissenter not associated with Whitney was John Muir, then a tatterdemalion vagrant. Though the two men never met, conflict between their inflexible and mutually exclusive geological theories (...) persisted well into the twentieth century. Eventually, both dogmatists were proved wrong, but Muir had come closer to what we now accept. Several geological and geomorphological issues of importance entered into later discussions of Yosemite. The whole controversy, moreover, illuminates such further issues as the influence of preconceptions on theorizing, the role of authority in science, and the interactions of professionals with amateurs. (shrink)